Perturbation of the Treatment of Resistant Depression Connectome by Fast-Acting Therapies (PDC)

Task Protocols for Treatment-Resistant Depression Connectome

CARIT (Conditioned Go/NoGo) Task

The CARIT (Conditioned Approach Response Inhibition Task, a Go/NoGo task without a reward history component) task is exactly the same as used in the Lifespan Aging and Development projects:

For this task's application in this cohort, also see:

Sahib AK, Loureiro JR, Vasavada MM, Kubicki A, Wade B, Joshi SH, Woods RP, Congdon E, Espinoza R, Narr KL. Modulation of inhibitory control networks relate to clinical response following ketamine therapy in major depression. TranslPsychiatry. 2020 Jul 30;10(1):260. doi: 10.1038/s41398-020-00947-7. PMID:32732915; PMCID: PMC7393172.

Face-Matching Task

The Face-Matching task we are using is a variation of the Emotion Recognition task used in the Young Adult HCP that was modified and shared as the Emotion Processing task by the BANDA project, another CRHD. 

For this task's application in this cohort, also see:

Loureiro JRA, Leaver A, Vasavada M, Sahib AK, Kubicki A, Joshi S, Woods RP, Wade B, Congdon E, Espinoza R, Narr KL. Modulation of amygdala reactivity following rapidly acting interventions for major depression. Hum Brain Mapp. 2020 May;41(7):1699-1710. doi: 10.1002/hbm.24895. Epub 2020 Mar 1. PMID:32115848; PMCID: PMC7268016.

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