Phase 1 Candidate Paradigms for Task-fMRI and Task MEG
|Domain(s)||Task||Comparisons||Regions of Interest|
Visual, Somatosensory Motor
Localizer: [1-3]; Reliable Across subjects [1, 2] and time 
Finger Responses (1)
|Phase-encoding Retinotopic Mapping
Event-related target responses vs. baseline (with Finger Responses vs. Fixation)
|Primary Motor; Premotor;
Striatum; Retinotopic Visual Areas
Localizer: [5-8]; Reliable across subjects [5, 6] and time [8, 9]
|Alternating blocks of 0-back and 2-back working memory; faces, non-living man-made objects, animals, body parts, houses, or words.||Each Stimulus Type compared to all other stimulus types||Fusiform; Occipital Face Areas; Superior Temporal Sulcus; Lateral Occipital;
Visual Word Form Area
Working Memory; Cognitive Control
Localizer: ; Reliable across subjects  and time 
|N-back Task (2-back versus 0-back) embedded in Category Specific Representation Task||2-back (average across stimulus types) vs. 0-back (average across stimulus types)||Dorsolateral + anterior Prefrontal; Inferior Frontal; Precentral Gyrus;Anterior Cingulate; Dorsal Parietal|
Dorsal Attention System
Reliable across subjects and robust activation in both fMRI [11, 12]
|Variant of Posner Task [compare 1) blocked and 2) event related versions]||
1) Mostly Incongruent Blocks vs. Mostly Congruent Blocks;
2) Incongruent Trials vs Congruent Trials
|Frontal Eye Fields; Supplementary Eye Fields; Precuneus; Intraparietal Sulcus: Anterior, Posterior Cingulate|
Localizer: [1, 13]; Reliable across subjects and robust activation in both fMRI and ERP [13, 14]
|Auditory sentence presentation with detection of semantic, syntactic and pragmatic violations||All sentences vs. fixation; Violation vs. no-violation||Inferior Frontal; Superior Temporal; Anterior Cingulate|
Localizer: [1, 15]; Reliable across subjects [1, 15] and time , robust activation in fMRI 
1) Valence Judgments (negative and neutral pictures or faces);
2) Hariri Hammer Task
1) Negative vs. neutral pictures,
2) Faces vs. shapes
|Amygdala; Hippocampus; Insula; Medial Prefrontal|
Localizer: [18, 19]; Reliable across subjects [18, 19] and time [18, 19]
|Remember, Know, New Recognition Judgements on Category-Specific task stimuli||Remember vs. Correct Rejections; Know vs. Correct Rejections||Parietal; Hippocampus; Entorhinal Cortex|
Reward & Decision Making
Localizer: ; Reliable across subjects and robust activation in fMRI [20-23]
|Gambling decision making task||Wins vs. Losses||Striatum; Ventral Medial Prefrontal; Orbitofrontal|
Reliable across subjects and robust activation in fMRI [24-26]
|Frith-Happe animations of social and random interactions||Social Interaction vs. Random Interaction||Medial prefrontal cortex; temporal parietal juction; inferior and superior temporal sulcus|
|Point light displays of biological motion vs. random motion vs. static dot displays||Biological motion vs. non-biological motion; non-biological motion vs. static displays||MT+; visual cortex|
Motor Strip Mapping
Localizer: [28, 29]
|Right versus left toe movements or finger movements; tongue movements||Each movement type compared to fixation; each movement type compared to the average of other movements types||Motor and somatosensory cortex|
- Drobyshevsky, A., S.B. Baumann, and W. Schneider, A rapid fMRI task battery for mapping of visual, motor, cognitive, and emotional function. Neuroimage, 2006. 31(2): p. 732-44.
- Hirsch, J., et al., An integrated functional magnetic resonance imaging procedure for preoperative mapping of cortical areas associated with tactile, motor, language, and visual functions. Neurosurgery, 2000. 47(3): p. 711-21; discussion 721-2.
- Gountouna, V.E., et al., Functional Magnetic Resonance Imaging (fMRI) reproducibility and variance components across visits and scanning sites with a finger tapping task. Neuroimage, 2009.
- Warnking, J., et al., fMRI retinotopic mapping--step by step. Neuroimage, 2002. 17(4): p. 1665-83.
- Fox, C.J., G. Iaria, and J.J. Barton, Defining the face processing network: optimization of the functional localizer in fMRI. Hum Brain Mapp, 2009. 30(5): p. 1637-51.
- Downing, P.E., et al., A cortical area selective for visual processing of the human body. Science, 2001. 293(5539): p. 2470-3.
- Taylor, J.C., A.J. Wiggett, and P.E. Downing, Functional MRI analysis of body and body part representations in the extrastriate and fusiform body areas. J Neurophysiol, 2007. 98(3): p. 1626-33.
- Peelen, M.V. and P.E. Downing, Within-subject reproducibility of category-specific visual activation with functional MRI. Hum Brain Mapp, 2005. 25(4): p. 402-8.
- Kung, C.C., J.J. Peissig, and M.J. Tarr, Is region-of-interest overlap comparison a reliable measure of category specificity? J Cogn Neurosci, 2007. 19(12): p. 2019-34.
- Caceres, A., et al., Measuring fMRI reliability with the intra-class correlation coefficient. Neuroimage, 2009. 45(3): p. 758-68.
- Doricchi, F., et al., Neural correlates of the spatial and expectancy components of endogenous and stimulus-driven orienting of attention in the Posner task. Cerebral cortex, 2010. 20(7): p. 1574-85.
- Engelmann, J.B., et al., Combined effects of attention and motivation on visual task performance: transient and sustained motivational effects. Frontiers in human neuroscience, 2009. 3: p. 4.
- Kuperberg, G.R., T. Sitnikova, and B.M. Lakshmanan, Neuroanatomical distinctions within the semantic system during sentence comprehension: evidence from functional magnetic resonance imaging. NeuroImage, 2008. 40(1): p. 367-88.
- Ditman, T., P.J. Holcomb, and G.R. Kuperberg, An investigation of concurrent ERP and self-paced reading methodologies. Psychophysiology, 2007. 44(6): p. 927-35.
- Phan, K.L., D.A. Fitzgerald, K. Gao, G.J. Moore, M.E. Tancer, and S. Posse, Real-time fMRI of cortico-limbic brain activity during emotional processing. Neuroreport, 2004. 15(3): p. 527-32.
- Manuck, S.B., S.M. Brown, E.E. Forbes, and A.R. Hariri, Temporal stability of individual differences in amygdala reactivity. Am J Psychiatry, 2007. 164(10): p. 1613-4.
- Hariri, A.R., et al., The amygdala response to emotional stimuli: a comparison of faces and scenes. NeuroImage, 2002. 17(1): p. 317-23.
- Miller, M.B., J.D. Van Horn, G.L. Wolford, T.C. Handy, M. Valsangkar-Smyth, S. Inati, S. Grafton, and M.S. Gazzaniga, Extensive individual differences in brain activations associated with episodic retrieval are reliable over time. J Cogn Neurosci, 2002. 14(8): p. 1200-14.
- Miller, M.B., C.L. Donovan, J.D. Van Horn, E. German, P. Sokol-Hessner, and G.L. Wolford, Unique and persistent individual patterns of brain activity across different memory retrieval tasks. Neuroimage, 2009. 48(3): p. 625-35.
- Delgado, M.R., et al., Tracking the hemodynamic responses to reward and punishment in the striatum. Journal of Neurophysiology, 2000. 84: p. 3072-3077.
- Tricomi, E.M., M.R. Delgado, and J.A. Fiez, Modulation of caudate activity by action contingency. Neuron, 2004. 41(2): p. 281-92.
- May, J.C., et al., Event-related functional magnetic resonance imaging of reward-related brain circuitry in children and adolescents. Biological psychiatry, 2004. 55(4): p. 359-66.
- Forbes, E.E., et al., Altered striatal activation predicting real-world positive affect in adolescent major depressive disorder. The American journal of psychiatry, 2009. 166(1): p. 64-73.
- Castelli, F., et al., Movement and mind: a functional imaging study of perception and interpretation of complex intentional movement patterns. NeuroImage, 2000. 12(3): p. 314-25.
- Castelli, F., et al., Autism, Asperger syndrome and brain mechanisms for the attribution of mental states to animated shapes. Brain : a journal of neurology, 2002. 125(Pt 8): p. 1839-49.
- White, S.J., et al., Developing the Frith-Happe animations: a quick and objective test of Theory of Mind for adults with autism. Autism research : official journal of the International Society for Autism Research, 2011. 4(2): p. 149-54.
- Peuskens, H., et al., Specificity of regions processing biological motion. The European journal of neuroscience, 2005. 21(10): p. 2864-75.
- Morioka, T., et al., Comparison of magnetoencephalography, functional MRI, and motor evoked potentials in the localization of the sensory-motor cortex. Neurological research, 1995. 17(5): p. 361-7.
- Bizzi, A., et al., Presurgical functional MR imaging of language and motor functions: validation with intraoperative electrocortical mapping. Radiology, 2008. 248(2): p. 579-89.