NIH Blueprint: The Human Connectome Project

Phase 1 Candidate Paradigms for Task-fMRI and Task MEG

Related pages: Task fMRI, Task MEG.

Domain(s) Task Comparisons Regions of Interest

Visual, Somatosensory Motor

Localizer: [1-3]; Reliable Across subjects [1, 2] and time [4]

(Phase Encoded)
Retinotopic Mapping
Finger Responses (1)

Phase-encoding Retinotopic Mapping
Event-related target responses vs. baseline (with Finger Responses vs. Fixation)

Primary Motor; Premotor;
Striatum; Retinotopic Visual Areas

Category-Specific Representations

Localizer: [5-8]; Reliable across subjects [5, 6] and time [8, 9]

Alternating blocks of 0-back and 2-back working memory; faces, non-living man-made objects, animals, body parts, houses, or words.

Each Stimulus Type compared to all other stimulus types

Fusiform; Occipital Face Areas; Superior Temporal Sulcus; Lateral Occipital;
Parahippocampal Gyrus;
Visual Word Form Area

Working Memory; Cognitive Control

Localizer: [1]; Reliable across subjects [1] and time [10]

N-back Task (2-back versus 0-back) embedded in Category Specific Representation Task

2-back (average across stimulus types) vs. 0-back (average across stimulus types)

Dorsolateral + anterior Prefrontal; Inferior Frontal; Precentral Gyrus;Anterior Cingulate; Dorsal Parietal

Dorsal Attention System

Reliable across subjects and robust activation in both fMRI [11, 12]

Variant of Posner Task [compare 1) blocked and 2) event related versions]

1) Mostly Incongruent Blocks vs. Mostly Congruent Blocks;

2) Incongruent Trials vs Congruent Trials

Frontal Eye Fields; Supplementary Eye Fields; Precuneus; Intraparietal Sulcus: Anterior, Posterior Cingulate

Language Processing

Localizer: [1, 13]; Reliable across subjects and robust activation in both fMRI and ERP [13, 14]

Auditory sentence presentation with detection of semantic, syntactic and pragmatic violations All sentences vs. fixation; Violation vs. no-violation Inferior Frontal; Superior Temporal; Anterior Cingulate

Emotion Processing

Localizer: [1, 15]; Reliable across subjects [1, 15] and time [16], robust activation in fMRI [17]

1) Valence Judgments (negative and neutral pictures or faces);

2) Hariri Hammer Task

1) Negative vs. neutral pictures,
negative vs. neutral faces

2) Faces vs. shapes

Amygdala; Hippocampus; Insula; Medial Prefrontal


Localizer: [18, 19]; Reliable across subjects [18, 19] and time [18, 19]

Remember, Know, New Recognition Judgements on Category-Specific task stimuli Remember vs. Correct Rejections; Know vs. Correct Rejections Parietal; Hippocampus; Entorhinal  Cortex

Reward & Decision Making

Localizer: [19]; Reliable across subjects and robust activation in fMRI [20-23]

Gambling decision making task

Wins vs. Losses

Striatum; Ventral Medial Prefrontal; Orbitofrontal

Social Cognition

Reliable across subjects and robust activation in fMRI [24-26]

Frith-Happe animations of social and random interactions Social Interaction vs. Random Interaction Medial prefrontal cortex; temporal parietal juction; inferior and superior temporal sulcus

Biological Motion

Localizer: [27]

Point light displays of biological motion vs. random motion vs. static dot displays Biological motion vs. non-biological motion; non-biological motion vs. static displays MT+; visual cortex

Motor Strip Mapping

Localizer: [28, 29]

Right versus left toe movements or finger movements; tongue movements Each movement type compared to fixation; each movement type compared to the average of other movements types Motor and somatosensory cortex



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